The effects of the methanol extract of Leea rubra roots Blume (L. rubra) on nociceptive
response using writhing, hot plate and formalin tests, and on pentobarbital-induced sleep in mice and the antipyretic activity of the extract in yeast-induced fever in rats, were examined. L. rubra extract (100-400mg/kg, p.o.) dose-dependently decreased the number of contortions and stretchings induced by acetic acid but not in the heat-induced pain. At the same dose range,, in the formalin test, the extract significantly reduced the duration of licking in the late phase but not in the early phase. The extract significantly reduced fever induced by yeast only at the high dose of 400 mg/kg. The L. urbra extract had no significant effect on pentobarbitalinduced sleep. These results suggest that tht L.rubra extract possesses peripheral antinociceptive and mild antipyretic effects and that the former effect seems to be involved in its anti-inflammatory action.