In the present study, a comparison between the separation power of capillary columns made with totally porous and
core–shell CSPs evaluated under nano-LC conditions showed that the latter material performed slightly better in terms of chiral selectivity and resolution for almost all studied chiral compounds (Fig. 3). This can be attributed to the morphology of core–shell silica (more uniform size of particles compared to totally porous silica), as well as to the slightly smaller nominal particle size of the core–shell particle-based material compared to the totally porous material.
Along these lines, the slightly better selectivity observed with the CSP based on core–shell particles can be attributed to the lower surface area of such particles (due to the presence of core) probably resulting in a somewhat thicker coated layer of chiral selector.