The main purpose of this study is to investigate the effect of multimedia computer assisted
instruction on student learning achievement using the high school curriculum entitled “molecules that dominate
secret of life” from high school biology. The results show that when compared to traditional models of
instruction, students using the multimedia computer assisted instruction model scored significantly better in
learning achievement assessments. Secondly, the study also discussed the combined effect of instruction model
and learning style on student learning achievement. The results show that students exposed to a converging
learning style with traditional instruction perform significantly better than those exposed to three other learning
styles. Nonetheless, students exposed to these same three other learning styles performed better when exposed
to the multimedia computer assisted instruction model. As a result, under the influence of multimedia
instruction, students exposed to the four learning styles (Diverger, Assimilator, Converger, and Accommodator)
do not shown any significant difference.