Dopamine plays an important role both centrally and peripherally. The recent identification of 5 dopamine receptor subtypes provides a basis for understanding dopamine's central and peripheral actions. Changes in central dopamine neurotransmission are implicated in processes as diverse as muscle rigidity, hormonal regulation, thought disorder and cocaine addiction. Peripheral dopamine receptors mediate changes in blood flow, glomerular filtration rate, sodium excretion and catecholamine release. Increased knowledge of the roles of dopamine receptor subtypes raises hopes that more selective drugs, associated with fewer adverse effects, will be developed.
Key words: dopamine receptors, dopamine agonists, dopamine antagonists, localisation, function
Dopamine plays an important role both centrally and peripherally. The recent identification of 5 dopamine receptor subtypes provides a basis for understanding dopamine's central and peripheral actions. Changes in central dopamine neurotransmission are implicated in processes as diverse as muscle rigidity, hormonal regulation, thought disorder and cocaine addiction. Peripheral dopamine receptors mediate changes in blood flow, glomerular filtration rate, sodium excretion and catecholamine release. Increased knowledge of the roles of dopamine receptor subtypes raises hopes that more selective drugs, associated with fewer adverse effects, will be developed.Key words: dopamine receptors, dopamine agonists, dopamine antagonists, localisation, function
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