The purpose of the study was to examine whether the Sensory Profile (Dunn, 1999) was an effective instrument to screen sensory processing abilities for Thai children, 5 to 10 years of age. In this study, the Sensory Profile was translated into Thai language and the accuracy of the translation was checked by the; back-translation, the agreement rating of the experienced therapists, and the English-Thai item correlation methods. The Thai version of the Sensory Profile (TSP) was then used to examine the sensory processing abilities of Thai children through their caregivers' reports. There were 120 caregivers who voluntarily filled out the TSP in this study. Sensory processing information of 60 Thai children without disabilities (NOR) and 60 Thai children with disabilities (DIS) was collected. The DIS was composed of 30 Thai children with autism (AU) or pervasive developmental disorder (PDD) and 30 Thai children with attention deficit hyperactive disorder (ADHD). The Pearson product moment correlation, Interclass correlation, multivariate analysis of variance, and discriminative analysis were performed. The results were shown that the internal consistency for 124 items was .96, while for the 14 sections was .91. The test-retest coefficient for a one-week period was .97. The sensory processing abilities between the DIS and the NOR were significantly different as well as those between the AU/PDD and the ADHD The patterns of children's sensory processing could be used to predict group membership. The accuracy of the differentiation between the NOR and the DIS was 90% and that between the AU/PDD and the ADHD was 91.7%. The accuracy of the differentiation among the NOR, the AU/PDD, and the ADHD was 89%. The results indicated that the internal consistency and the test-retest reliabilities and the construct validity of the TSP were satisfied. The TSP was a reliable and valid screening assessment tool to determine whether Thai children, ages 5 to 10 years old, have difficulty with sensory processing. It also provides informative clues to guide occupational therapists in more efficient evaluation and individually focused treatment.