Aloe verahas a long association with herbal medicine, although it is not known when its medical applications were first discovered.Aloe verais non-toxic, with no known side effects, provided the aloin has been removed by processing. Taking Aloe vera that contains aloin in excess amounts has been associated with various side effects. However, the species is used widely in the traditional herbal medicine of China, Japan, Russia, South Africa, The United States, Jamaica and India. Aloe vera is alleged to be effective in treatment of wounds.