The substantial advances made in the understanding of
the role of multifunctional polyketide synthase enzymes
(PKSs) in bacterial aromatic polyketide biosynthesis have
led to the identification of many such enzymes, together with
their encoding genes.118-121 The same applies to nonribosomal
peptide synthases (NRPS) responsible for the biosynthesis
of nonribosomal peptides (NRPs). Through the
analysis of microbial genomes, a multitude of gene clusters
encoding for polyketides, NRPs, and hybrid polyketide-NRP
metabolites have been identified, and the tools have been