Sunscreen filters, which block hazardous UV radiation, are commonly applied in cosmetic products to
protect the skin, the hair, or the product itself. Most sunscreen formulations are emulsions or creams.
However, formulations based on nanoparticles as the delivery vehicle for the sunscreen compounds
potentially have advantages in terms of retention on the skin, lack of penetration across the epidermal
layer and UV attenuation by both absorption and scattering. In this study, sunscreen nanoparticle
suspensions are prepared via the novel Flash NanoPrecipitation process (FNP), which involves rapid
micromixing followed by block copolymer directed assembly of nanoparticles. The block copolymer stabilizer
is polystyrene-block-polyethylene glycol (PS-b-PEG) with a homopolymer polystyrene (PS) as the
co-solute in the nanoparticle core. By changing the filter and/or PS concentration, stable nanoparticles
with sizes from 80 to 200 nm are prepared. Most importantly, FNP enables incorporation of both organic
and inorganic hydrophobic filters into nanoparticles, and thus offers broad-spectrum sun protection. The
nanocolloids offer enhanced UV protection because they attenuate light by both adsorption and scattering.
Three organic filters, ethylhexyl triazone (Uvinul T 150), benzophenone-3 (Uvinul M 40), and
diethylamino hydroxybenzoyl hexyl benzoate (Uvinul A Plus) and two nano-sized inorganic filters, zinc
oxide and titanium dioxide are examined. In addition it is found the polystyrene core material offers
significant UV blocking in the UVC range of 200–280 nm. Dynamic light scattering (DLS) reveals that the
nanoparticles’ size distribution is narrow and remains stable (over 80 days). The combination of organic
and inorganic filters enables tunable UV protection over the wavelength range 280–400 nm. In conclusion,
flash nanoprecipitation provides a new formulation method of encapsulating hydrophobic organic
and inorganic sunscreen filters.
Sunscreen filters, which block hazardous UV radiation, are commonly applied in cosmetic products toprotect the skin, the hair, or the product itself. Most sunscreen formulations are emulsions or creams.However, formulations based on nanoparticles as the delivery vehicle for the sunscreen compoundspotentially have advantages in terms of retention on the skin, lack of penetration across the epidermallayer and UV attenuation by both absorption and scattering. In this study, sunscreen nanoparticlesuspensions are prepared via the novel Flash NanoPrecipitation process (FNP), which involves rapidmicromixing followed by block copolymer directed assembly of nanoparticles. The block copolymer stabilizeris polystyrene-block-polyethylene glycol (PS-b-PEG) with a homopolymer polystyrene (PS) as theco-solute in the nanoparticle core. By changing the filter and/or PS concentration, stable nanoparticleswith sizes from 80 to 200 nm are prepared. Most importantly, FNP enables incorporation of both organicand inorganic hydrophobic filters into nanoparticles, and thus offers broad-spectrum sun protection. Thenanocolloids offer enhanced UV protection because they attenuate light by both adsorption and scattering.Three organic filters, ethylhexyl triazone (Uvinul T 150), benzophenone-3 (Uvinul M 40), anddiethylamino hydroxybenzoyl hexyl benzoate (Uvinul A Plus) and two nano-sized inorganic filters, zincoxide and titanium dioxide are examined. In addition it is found the polystyrene core material offers
significant UV blocking in the UVC range of 200–280 nm. Dynamic light scattering (DLS) reveals that the
nanoparticles’ size distribution is narrow and remains stable (over 80 days). The combination of organic
and inorganic filters enables tunable UV protection over the wavelength range 280–400 nm. In conclusion,
flash nanoprecipitation provides a new formulation method of encapsulating hydrophobic organic
and inorganic sunscreen filters.
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