This study demonstrates that antioxidant supplementation of the diet reduces ROS and DNA
damage, prevents p53 activation, and markedly increases tumor cell proliferation and tumor
growth in mice. The data demonstrate that tumor cells proliferate faster when oxidative stress
is suppressed. This reasoning is consistent with previous studies showing that oncogenes stimulate NRF2-mediated expression of endogenous antioxidants, reduce ROS, and thereby increase tumor cell proliferation