The results of time course experimental revealed that the antifungal production by Streptomyces sp. SY-BS5 strain was growth dependent. The isolate had highest antifungal activ- ity and biomass production at 9 days of incubation on ISP2 medium which was composed of 4.0 g/L glucose, 4.0 g/L yeast extract and 10.0 g/L malt extract at pH 8.5 and 3% NaCl (Fig. 3).