The inner core contains the doudble-stranded deoxyribonucleic acid (DNA) genome, which for EAdV1 is 43.4 kb in length. Restriction endonuclease maps and genome orientation data were published for EAdV1, and genomic sequence data for both viruses were also published.
Nucleotide sequence data for the EadV2 genome corroborated at the molecular level that EAadV2 is distinct from EAdV1 and that the two viruses evolved separately. Cavanagh et al requenced the EAdV1 genome. An unexpected finding was the similarity to two other recently characterized bat adenoviruses.