Separations were carried out on a 50 × 2.1 mm Atlantis T3C18 (3 m), column (Waters, St-Quentin-en Yvelines, France) protected with a 10 × 2.1 mm pre-column filled with the same stationary phase. All experiments were carried out at 25 ◦C at a flow-rate of 0.3 mL/min. The mobile phase consisted of 1% formic acid in a mixture of water/acetonitrile (30/70, v/v). 84 mg of the dry residue of the extract are dissolved in 10 ml of methanol. After dilution in water (1/1, v/v) and centrifugation (15 min at 2000 × g), the super