The committee noted the addition of 2 new small, level 2 RCTs (Moses 2009 and Chourdakis 2012), since the last update and
despite the modest changes in the overall treatment effect of on mortality & infections, there were no other changes in the other overall scoring of
values (confidence intervals, validity, reproducibility, adequacy of control group, etc. See table below). The committee noted the results of a large
observational study of 1174 critically ill patients on vasopressors that demonstrated early enteral nutrition was associated with decreased hospital
mortality and that the beneficial effect of early feeding was more evident in patients treated with multiple vasopressors
(1).
The committee agreed that
based on the updated evidence and the unchanged scoring of values, the recommendation for early vs delayed enteral nutrition remain as
“recommend”.
The committee noted the addition of 2 new small, level 2 RCTs (Moses 2009 and Chourdakis 2012), since the last update and despite the modest changes in the overall treatment effect of on mortality & infections, there were no other changes in the other overall scoring of values (confidence intervals, validity, reproducibility, adequacy of control group, etc. See table below). The committee noted the results of a large observational study of 1174 critically ill patients on vasopressors that demonstrated early enteral nutrition was associated with decreased hospital mortality and that the beneficial effect of early feeding was more evident in patients treated with multiple vasopressors(1).The committee agreed that based on the updated evidence and the unchanged scoring of values, the recommendation for early vs delayed enteral nutrition remain as “recommend”.
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