Treatment of ESFT consists of two major components: systemic chemotherapy and local control. These two com- ponents are carried out in three phases: (1) induction che- motherapy, the goal of which is to achieve rapid initial cytoreduction and facilitate local control; (2) local control usingsurgery,radiationtherapy,orboth,usuallyafter10to 12 weeks of induction chemotherapy; and (3) continuation therapy,whichconsistsofchemotherapeuticregimenssimi- lartothoseusedforinduction[87].