Zika virus is found that mosquito-borne flaviviruses initially replicate in dendritic cells close to the inoculation site and then spread to lymph nodes and the blood. Although flaviviral replication is found to occur in cellular cytoplasm, studies suggest that ZIKV antigens can be found in nucleus of the infected cells. Moreover, infectious ZIKV has been detected in human blood before the beginning of symptoms. After the replication, ZIKV may distribute from the lymphatics and blood stream to infect other organs of the body such as myocardium, central nervous system, skeletal muscles and to the fetus. The virus replication in astroglial cells and neurons in the brain of infected suckling mice result in neuronal degeneration, cellular infiltration and alleviation in the brain. Further-more, the evidence of inflammation is found in myocardium and skeletal muscles in the infected mice. The neurotropism and tenacity