Estrogen preparations are currently the only US Food and Drug Administration (FDA)-approved medication for the treatment of sexual dysfunction. Small doses of estrogen vaginal cream can adequately improve lubrication and decrease pain with intercourse; however, estrogen response is quite individual.5 Drug efficacy may be affected by the route of estrogen administration. Clinical evidence has shown that 0.625 mg of conjugated estrogen or an equipotent dose of another estrogen product is sufficient for most women as hormone replacement therapy to improve sexual dysfunction symptoms