A new intradermal needle RF device (INNOfill;
Pacific Pharma, Korea) was assessed in the present study. In
the animal arm, procollagen production was measured by
using enzyme-linked immunosorbent assay, the filler volume
was quantified by incorporating a dye with filler, and
the filler distribution was assessed through the changes in
tissue structure. In the human arm, the efficacy of the combination
regimen was assessed by using the wrinkle severity
rating scale (WSRS).