All animal experiments should be carried out in accordance with the U.K. Animals (Scientific
Procedures) Act, 1986 and associated guidelines, EU Directive 2010/63/EU for animal experiments,
or the National Institutes of Health guide for the care and use of Laboratory animals (NIH Publications
No. 8023, revised 1978) and the authors should clearly indicate in the manuscript that such
guidelines have been followed. All animal studies need to ensure they comply with the ARRIVE
guidelines. More information can be found at http://www.nc3rs.org.uk/page.asp?id=1357.