For example, in a study of 6,000 men followed for 14 years, each 500 kcal/week increase in physical activity reduced the age-adjusted risk of diabetes by 6% (18). Behavioral weight loss studies with diabetic (19) and nondiabetic participants (13) have often used a 1,000 kcal/week activity goal. In the DPP, the 150-min weekly physical activity goal was selected because it was similar to the newest public health recommendations (20) as well as the Surgeon General’s Report on Physical Activity and Health (21).