Adherence to medication regimens has been monitored
since the time of Hippocrates, when the effects
of various potions were recorded with notations
of whether the patient had taken them or not.
Even today, patients’ self-reports can simply and
effectively measure adherence.
28,29
The methods
available for measuring adherence can be broken
down into direct and indirect methods of measurement
(Table 1). Each method has advantages and
disadvantages, and no method is considered the
gold standard