KNIMEs core-architecture allows processing of large data volumes that are only limited by the available hard disk space (most other open source data analysis tools are working in main memory and are therefore limited to the available RAM). E.g. KNIME allows analysis of 300 million customer addresses, 20 million cell images and 10 million molecular structures.
Additional plugins allows the integration of methods for Text mining, Image mining, as well as time series analysis.
KNIME integrates various other open-source projects, e.g. machine learning algorithms from Weka, the statistics package R project, as well as LIBSVM, JFreeChart, ImageJ, and the Chemistry Development Kit.[10]
KNIME is implemented in Java but also allows for wrappers calling other code in addition to providing nodes that allow to run Java, Python, Perl and other code fragments.