The loss of muscle mass (sarcopenia)and the associated reduced muscle strength are key limiting factors for elderly people's quality of life. Improving muscle preformance does not necessarily correlate with increasing muscle mass. In fact,particularly in the elderly,the main explanation for muscle weakness is a reduction of muscle quality rather than a loss of muscle mass, and the main goal to be achieved is to increase muscle strength.The effectiveness of Trimetazidine(TMZ) in preventing muscle function impairment during ageing was assessed in our laboratory.