MATERIALS MATERIALS
Metoclopramide hydrochloride (MTH) was
gift samples from Comed Chemicals Ltd, Baroda
(India). Directly compressible mannitol (Pearlitol SD
200), microcrystalline cellulose (MCC, PH-102) and
sodium stearyl fumerate (SSF) were generous gifts
from Strides Arcolabss, Bangalore (India). All theother chemicals used were of analytical reagent
grade.
METHODS METHODS
Preparation of Co-processed Superdisintegrants11
The co-processed superdisintegrants were
prepared by solvent evaporation method. A blend of
crospovidone and sodium starch glycolate (in the
ratio of 1:1, 1:2 & 1:3) was added to 10 ml of
ethanol. The contents of the beaker (250 ml capacity)
were mixed thoroughly and stirring was continued till
most of ethanol evaporated. The wet coherent mass
was granulated through # 44-mesh sieve. The wet
granules were dried in a hot air oven at 60º C for 20
minutes. The dried granules were sifted through # 44-
mesh sieve and stored in airtight container till further
use