An optimal CAUTI prevention program should also consider multiple aspects of catheter design. Robust research reviewed in part 1 of this Evidence-Based Report Card supports the use of antimicrobial catheters, either silver alloy hydrogel catheters or antibiotic impregnated silicone catheters for short-term catheterization.Expert opinion suggests that selection of a 14–16 French catheter, in preference to catheter sizes 18 French or larger, may reduce urethral irritation and inflammation, but there is insufficient evidence to confirm or refute this recommendation. A single randomized clinical trial was identified in this review that suggests that catheter securement does not reduce CAUTI risk, but additional evidence is required before drawing a firm conclusion about this issue. Routine catheter securement is strongly recommended based on safety considerations in patients with short-term indwelling catheters and for the prevention of urethral erosion in patients with long-term indwelling catheters.