Object Increased intracranial pressure (ICP) in patients with traumatic brain injury (TBI) is associated with a higher
mortality rate and poor outcome. Mannitol and hypertonic saline (HTS) have both been used to treat high ICP, but it is
unclear which one is more effective. Here, the authors compare the effect of mannitol versus HTS on lowering the cumulative
and daily ICP burdens after severe TBI.