Nine infected dogs showed skin
lesions at the beginning of the trial, which disappeared after treatment in 7 dogs, whereas
the other two symptomatic dogs did not show any dermatological improvement until the
end of the trial even though they scored negative for D. repens microfilariae. This study
demonstrated that a single dermal administration of Advocate® is effective in eliminating
microfilariae of D. repens and likely has a certain degree of activity in killing subcutaneous
adult worms as well. This study demonstrates the efficacy of Advocate® in the treatment of
dermatitis caused by D. repens. Also, these results are of importance towards further control
programs aiming to reduce the number of bites infectious for mosquitoes and the risk of
infection for both humans and dogs.