in humans also known as multi- drug resistant p-glycoprotein MDR3, acts as a ‘flip- pase’ that translocates phospholipids from the inner to the outer leaflet of the membrane [41]. Mutations in the MDR3 gene were first described in progressive familial intrahepatic cholestasis (PFIC) type 3 [42] and later found in a number of hepatobiliary diseases [43], including cholesterol gallstone disease [44] and intrahepatic cholestasis of pregnancy (ICP) [45, 46]. ABCB11