would be exhausted by the proposed project, the HIVV PMO will collaborate with the Scientific Review board, the PI, and the investigators to reach consensus on last-sample use or to identify other volunteer-timepoint pairs that could satisfy the requirements of the proposed research without consuming the final material. A sample set will be produced indicating specific samples and data to be released. The HIVV PMO will ensure that all of the above requirements are met before forwarding the sample set for final approval by the principal investigator.