hence may be attributed to the effects of negative energy balance in all groups, suggesting that suppression of sympathetic activation by weight-loss programs, either caloric restriction or exercise, may have an important role in weight loss-induced BP reduction.
In our previous study in obese Caucasian subjects with
the metabolic syndrome, weight loss over 12 weeks with D+EX was
associated with significantly greater decreases in total body fat mass,
abdominal fat mass and waist-to-hip ratios than the D alone group,
but reduction in plasma NE and NE spillover were greater in the D
alone group compared with the combination group with D+EX.52 The
groups, including those in the EX program, had earlier and stronger
improvements on HOMA-IR.