These results confirm that ABCC10 is involved in the efflux
transport of TFV. Renal elimination is the dominant mode of
TFV clearance, and these findings add to our understanding of
the molecular pharmacology of TFV. ABCC10 mRNA has been
found to be highly expressed in various tissues including kidney,
brain and colon, suggesting an important role for this protein in
the transport of drugs and other endogenous molecules.