Nonetheless, scores ranging from −2 to 10 likely define a continuous gradient of risk and benefit. The model used to derive the point values for variables required an assumption that bleeding and ischemic events were of equal weight. However,examination of the results stratified by score quartile allows assessment of different score cutoffs with varied weighting of bleeding and ischemic events, as well as examination of the association of the score with other relevant end points, including bleeding events not classified as moderate or severe. The ischemic and bleeding events as defined in this analysis may not have an equivalent effect on patient outcomes, including mortality, and the results may have been different had other ischemic and bleeding end points been chosen