The CamKII-Cre × flBDNF mice were also examined for their behavioral response to subchronic antidepressant treatment. Mice were administered saline or desipramine (10 mg/kg; 10 mg/kg; 20 mg/kg) by IP injections 24 hours, 4 hours, and 1 hour before the test. (C) Antidepressant (AD) treatment significantly reduced immobility time in male WT mice (n = 8; p < .05) but not in the BDNF conditional KOs (n = 9).