This information
is then received and processed in the hypothalamus,
which controls the activity of the sympathetic nervous system(SNS), leading to release of norepinephrine (NE) onto brown and
beige fat cells. NE works through G protein-coupled β-adrenergic
receptors (β-ARs) on adipocytes to activate the cAMP/Protein
Kinase A/cAMP response element-binding protein signaling
cascade that controls the transcription of the thermogenic
gene program.