fixed oil of o.sanctum produced hypotensive effect in anaesthetized dog, probably due to its peripheral vesodilatory action. the oil increased blood-clotting time and percentage increase in clotting time was comparable to aspirin and could be due to inhibition of platelet aggregation. the oil also increased pentobarbitoneinduced sleeping time in rets indicating probable inhibitory effect of oil towards cytochromic enzyme responsible for hepatic metabolism of pentobarbitone.