In summary, Hb E variant, which is common in the North-eastern part of India, can interfere with the HbA1C measurement depending on the type of assay used.[13] Even if HbA1C is detectable by immunoassay, it is often an underestimate. A different technique, which might not affect the HbA1C, should be tried.[14] Hb electrophoresis must be done to look for hemoglobinopathies in such cases. It is important to consider the risks of inappropriate HbA1C measurements in persons with diabetes, and its impact on treatment. Any result that does not fit the clinical picture should be investigated further.