Heuristically, all
of these combinations attempt to increase the delicate balance
of cerebral neurotransmitters including serotonin, dopamine, and norepinephrine in specific areas of the brain through the
mechanism of reuptake inhibition or alternately for other SNRIs
and mirtazapine, by synergistically inhibiting reuptake by the
SNRI and subsequentially increasing release of serotonin and
norepinephrine into the synapse (Trivedi and Daly, 2008; Philip et
al., 2010; Shelton et al., 2010).
Heuristically, allof these combinations attempt to increase the delicate balanceof cerebral neurotransmitters including serotonin, dopamine, and norepinephrine in specific areas of the brain through themechanism of reuptake inhibition or alternately for other SNRIsand mirtazapine, by synergistically inhibiting reuptake by theSNRI and subsequentially increasing release of serotonin andnorepinephrine into the synapse (Trivedi and Daly, 2008; Philip etal., 2010; Shelton et al., 2010).
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