To achieve a cure for HIV, the efforts of the global research community need to be coordinated and transparent in sharing both positive and negative clinical results (panel). The discovery of a cure is one of the major medical challenges of our time. This goal has rallied all sectors of the biomedical community—ie, public, private, academic, and community groups, and consultation has led to the elaboration of a document that describes a strategy leading to a cure.14 Many challenges are associated with the identification of combinatorial approaches that can effectively induce reactivation of the latent reservoirs and enhance specific immune responses to control virus replication and eliminate virus-infected cells. Additionally, ethical issues need to be addressed in strategies that reactivate virus infection in individuals who are successfully treated with ART. Findings of recent studies show that immediate or early treatment with ART after infection could minimise the size and complexity of the latent reservoir, and might lead to post-treatment control. These results should provide us with the optimism to move forward with therapeutic interventions aimed at the eradication of HIV infection. Presently, prevention and early initiation of ART is the best way to control the HIV pandemic.