In this study, in order to rapidly breed a new WDR cultivar with early maturity and blast resistance, the molecular markers of the rice blast resistance genes Pi-ta and Pi-b were used to conduct gene pyramiding in segregating generation materials. In combination with RGA technology and multi-site shuttle identi- fication of traits, the new WDR cultivar Huhan 106 with high quality, high yield, blast resistance, and early maturity was bred. Our results suggest that the pyramiding of favorable traits and the value-added improvement of varieties can be quickly and effi- ciently achieved by the combined use of MAS and RGA.