The tree leaves and seeds of Moringa oleifera Lam. was shown in Fig. 1. The aqueous leaf extract of Moringa oleifera did not produce any mortality when administered orally at various doses of 400 mg/kg to 6.4 g/kg, but reduced locomotion and dullness were observed in some animals treated with higher doses of 3200 and 6400 mg/kg 2 h post-treatment. The intraperitoneal (i.p.) route administration showed 20% and 80% mortality at the higher doses of 1000 and 2000 mg/kg. The LD50 was estimated to be 1585 mg/kg using a probit analysis method (Tables 1 and 2). There were no significant
differences (p ≥ 0.05) in the percentage weight gain of rats treated with Moringa oleifera (250, 500 and 15000 mg/kg) in comparison with the control rats (Table 3).