Hypersensitivity to enoxaparin, heparin or other LMWH. Bleeding tendencies; organic lesion w/ tendency to bleed; clinically significant active bleeding; intracerebral hemorrhage, severe renal failure, spinal or epidural anesth. Acute extensive ischemic stroke, acute infections endocarditis, mild to moderate kidney failure (CrCl 30 & 60 mL/min).