This study was conducted in Salvador, a city located in the northeastern coastal region of Brazil with a population of over 2.8 million and with a high reported prevalence of asthma in previous surveys [19]. To study the potential role of helminth infections in the high prevalence of allergy and asthma, we explored the effects of single or multiple helminth co-infections with A. lumbricoides, T. trichiura and Toxocara spp., on the occurrence of several allergy-associated outcomes. We observed a positive association between number of helminth infections and peripheral blood eosinophilia, elevated total IgE, spontaneous production of IL-10 and helminth antigenstimulated production of Th2 cytokines. The number of
helminth infections was inversely associated with allergen SPT and positively associated with IL-10 production by
non-stimulated blood cells, but had no significant effect
on the risk of asthma.
This study was conducted in Salvador, a city located in the northeastern coastal region of Brazil with a population of over 2.8 million and with a high reported prevalence of asthma in previous surveys [19]. To study the potential role of helminth infections in the high prevalence of allergy and asthma, we explored the effects of single or multiple helminth co-infections with A. lumbricoides, T. trichiura and Toxocara spp., on the occurrence of several allergy-associated outcomes. We observed a positive association between number of helminth infections and peripheral blood eosinophilia, elevated total IgE, spontaneous production of IL-10 and helminth antigenstimulated production of Th2 cytokines. The number of
helminth infections was inversely associated with allergen SPT and positively associated with IL-10 production by
non-stimulated blood cells, but had no significant effect
on the risk of asthma.
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