While electrophiles, such asHNE, have been identified
as significant modulators of cell function and signaling, studies have barely scratched the surface in identifying the critical protein and gene mediators underlying HNE’s multifarious cellular effects. In the
following review, we will discuss the generation of lipid electrophiles from their oxidative phospholipid parent compounds. Additionally, we will describe the important scientific efforts to identify protein and
gene targets of reactive lipid electrophiles