In the translation to clinical practice, eHealth technologies have an important role as “clinician extenders” (e.g., adjuncts to formal treatment, support system during continuing care). Pioneering work to develop and evaluate an integrated eHealth system of delivery for alcohol treatment and recovery management (see the article by Quanbeck) holds promise for the use of technology to optimize doctor–patient communication and to sustain treatment gains over time. However, eHealth faces challenges in the translation to clinical practice. Such challenges include maintaining the user’s interest for extended periods of time through, for example, the use of persuasive technologies. These technologies are explicitly designed to change the user’s attitudes or behaviors during an electronic interaction using methods of persuasion or social influence (see the article by Muench). Another important consideration is the need to address the ethical issues in eHealth research and intervention delivery related to confidentiality and privacy (see the article by Arora). Perhaps the greatest challenge to widespread adoption of eHealth technologies involves the need for a new model of health care that integrates in-person and eHealth technologies across the continuum of care (Marsch 2012), and that explicitly acknowledges the usefulness of personal monitoring and dynamic, adaptive, interactive interventions delivered just in time to foster healthy behaviors (Riley et al. 2011).