Current treatment guidelines recommend use of NK-1 receptor antagonists for regimens containing an anthracycline plus cyclophosphamide, but not for moderately emetogenic chemotherapy, although both the National Comprehensive Cancer Network and the American Socieity of Clinical Oncology allow use of NK-1 receptor antagonists at the clinician’s discretion. Therefore, patients in the active control group who received an anthracycline plus cyclophosphamide regimen could have been assigned an NK-1 receptor antagonist after completion of cycle 1.