Clinical findings
The low sensitivity and specificity of most of the relevant
neurologic symptoms has been largely demonstrated by several
clinical trials. Prodromal stage 7 days, optic atrophy on fundal
examination, focal deficit and abnormal movements were found to
be independently predictive of TBM (p < 0.007) in a group of children
aged 1 months to 12 years,9 but optic atrophy is usually a late
occurrence and abnormal movements are rare.