This indicates that island-type geographical areas have intrinsic differences from continental areas, both in climate impact and in causes of HFMD. Since HFMD strikes East Asia every year and there are no effective phar- maceutical treatments for this disease,integrated surveillance with timely multiple surveillance sources and meteorological information in different countries can assist in the controland mitigation of the impacts of HFMD in Eas tAsia.Also,these results can be applied to islands in other oceans for predicting HFMD or other in fectious diseases.