The effects of physiologically relevant doses of EGCG on
obesity and high-fat–induced pathologies associated with the
metabolic syndrome have not been systematically studied. The
goals of this study were to determine the effect of dietary EGCG
on weight gain, markers of insulin resistance, hepatic steatosis,
and inflammatory markers in a high-fat diet-induced mouse
model for obesity and the metabolic syndrome.We studied both
the long-term effects of EGCG in growing high-fat–fed mice and
the short-term effects of EGCG in 3-mo-old obese mice.