The effects of 4-hydroxy-3(2H)-furanones on H2O2 generated
by human PMNs stimulated by TPA were studied.
HDMF is the most potent, showing about 90% inhibition
at 90 μM. The IC50 values for HDMF, HEMF and HMF are
39, 44 and 55 μM, respectively (Fig. 6). This order correlated
with their anticarcinogenic activity against BP-induced
mouse forestomach neoplasms.