Clinical: Documentation of three separate ischemic episodes requiring unplanned hospitalization (inpatient or observation status), each requiring revascularization (three separate percutaneous coronary intervention [PCI] procedures or two PCI and one coronary artery bypass graft [CABG] procedure) if amenable to revascularization, within a consecutive 12-month period;
OR
Exercise stress test (with or without imaging): Ischemic response defined by ST-segment depression of greater than or equal to 1 mm measured 0.08 seconds after the J-point that is horizontal or downsloping in configuration or ST-segment elevation greater than or equal to 1 mm in leads without Q