The functions of class II MHC-associated invariant chains and HLA-DM. Class II molecules with bound invariant chain, or CLIP, are transported into vesicles, where the CLIP is removed by the action of DM.
Antigenic peptides generated in the vesicles are then able to bind to the class II molecules.
Another class II–like protein, called HLA-DO, may regulate the DM-catalyzed removal of CLIP. CIIV, class II vesicle.